Plasmodium vivax spleen-dependent genes encode antigens associated with cytoadhesion and clinical protection

Abstract excerpt

Plasmodium vivax , the most widely distributed human malaria parasite, causes severe clinical syndromes despite low peripheral blood parasitemia. This conundrum is further complicated as cytoadherence in the microvasculature is still a matter of investigations. Previous reports in Plasmodium knowlesi , another parasite species shown to infect humans, demonstrated that variant genes involved in cytoadherence were...

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