Article
Highly accurate mtGenome haplotypes from long-read SMRT sequencing can distinguish between monozygotic twins.
Forensic science international. Genetics - 1 Jul 2020
Chen Lu, Wang Jiaqian, Tan Lu, Lu Chaolong, Fu Guangping, Fu Lihong, Zhang Xiaojing, Wang Qian, Ma Chunling, Cong Bin, Li Shujin
Abstract excerpt
Discriminating between monozygotic twins (MZ) remains a challenge in the field of forensics globally. It is very difficult to find sequence variants within MZ twins, despite using ultra-deep next generation sequencing (NGS) for nuclear DNA. However, mitochondrial DNA might be a potential marker owing to its higher mutation rate and easier sequencing via NGS. Here, we aimed to introduce a long-read single molecule...
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