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Article

KIR and HLA-C genes in male infertility.

Journal of assisted reproduction and genetics - 1 Aug 2020

Wilczyńska Karolina, Radwan Paweł, Krasiński Rafał, Radwan Michał, Wilczyński Jacek R, Malinowski Andrzej, Barcz Ewa, Nowak Izabela

Abstract excerpt

PURPOSE: Approximately 50% of men reporting to clinics for assisted reproduction have abnormal sperm parameters; we therefore considered whether they differ from fertile males in terms of the frequency of KIR and HLA-C genes, suggesting the involvement of NK cells and some T cells in the inflammatory reaction that can occur in the testes, vas deferens, or epididymis. METHOD: We tested a total of 1064 men: 445 of...

Topics

Abortion, Habitual
Adult
Female
Fertilization in Vitro
Gene Frequency
Genotype
HLA-C Antigens
Haplotypes
Humans
Infertility, Male
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Receptors, KIR

Receptors, KIR2DL2

Receptors, KIR2DL5

Source

Open in PubMed Open full text

Identifiers

PMID: 32436047
DOI: 10.1007/s10815-020-01814-6
PMCID: PMC7467998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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