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Article

The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2020

McCuaig Sarah, Barras David, Mann Elizabeth H, Friedrich Matthias, Bullers Samuel J, Janney Alina, Garner Lucy C, Domingo Enric, Koelzer Viktor Hendrik, Delorenzi Mauro, Tejpar Sabine, Maughan Timothy S, West Nathaniel R, Powrie Fiona

Abstract excerpt

PURPOSE: The cytokine IL22 promotes tumor progression in murine models of colorectal cancer. However, the clinical significance of IL22 in human colorectal cancer remains unclear. We sought to determine whether the IL22 pathway is associated with prognosis in human colorectal cancer, and to identify mechanisms by which IL22 can influence disease progression. EXPERIMENTAL DESIGN: Transcriptomic data from stage...

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PMID: 32430479
DOI: 10.1158/1078-0432.CCR-19-1086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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