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The IL-22 gene rs2227478 polymorphism significantly decreases the risk of colorectal cancer in a Han Chinese population.

Pathology, research and practice - 1 Dec 2021

Jin Yuchen, Meng Linghan, Yang Haoyi, Cheng Sirui, Xiao Yiting, Wang Xingru, Feng Xianhong, Xiong Qiantao, Chen Bifeng

Abstract excerpt

To examine the role of IL-22 gene in colorectal cancer (CRC) susceptibility, we identified causative genetic polymorphisms in promoter region of IL-22 gene and explored the mechanism underlying their contribution to CRC development in a Chinese population of Hubei province. 13 target single nucleotide polymorphisms (SNPs) in IL-22 gene promoter were genotyped in 787 CRC patients (426 colon cancer and 361 rectal...

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PMID: 34808559
DOI: 10.1016/j.prp.2021.153690

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