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Article

A near full-length HIV-1 genome from 1966 recovered from formalin-fixed paraffin-embedded tissue.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2020

Gryseels Sophie, Watts Thomas D, Kabongo Mpolesha Jean-Marie, Larsen Brendan B, Lemey Philippe, Muyembe-Tamfum Jean-Jacques, Teuwen Dirk E, Worobey Michael

Abstract excerpt

With very little direct biological data of HIV-1 from before the 1980s, far-reaching evolutionary and epidemiological inferences regarding the long prediscovery phase of this pandemic are based on extrapolations by phylodynamic models of HIV-1 genomic sequences gathered mostly over recent decades. Here, using a very sensitive multiplex RT-PCR assay, we screened 1,645 formalin-fixed paraffin-embedded tissue...

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Cell Lineage
Democratic Republic of the Congo
Evolution, Molecular
Genome, Viral
HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Paraffin Embedding

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PMID: 32430331
DOI: 10.1073/pnas.1913682117
PMCID: PMC7275743

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