Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations.

BMC bioinformatics - 19 May 2020

Ravkin Hersh D, Givton Ofer, Geffen David B, Rubin Eitan

Abstract excerpt

BACKGROUND: Compared to the many uses of DNA-level testing in clinical oncology, development of RNA-based diagnostics has been more limited. An exception to this trend is the growing use of mRNA-based methods in early-stage breast cancer. Although DNA and mRNA are used together in breast cancer research, the distinct contribution of mRNA beyond that of DNA in clinical challenges has not yet been directly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Gene Expression
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasm Recurrence, Local

Share to Prognosis

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 32429832
DOI: 10.1186/s12859-020-3512-z
PMCID: PMC7236449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Direct comparison shows that mRNA-based diagnostics incorporate information which cannot be learned directly from genomic mutations.PMID 32429832Read ↗

Real-world Evidence of Diagnostic Testing and Treatment Patterns in US Patients With Breast Cancer With Implications for Treatment Biomarkers From RNA Sequencing DataSemantic proximity Read ↗

Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score.Semantic proximity Read ↗

Classification of Breast Cancer Using Genetic Algorithms and Tissue MicroarraysSemantic proximity Read ↗

Avoiding test set bias with rank-based predictionSemantic proximity Read ↗

Comparison of the RNA-based EndoPredict multigene test between core biopsies and corresponding surgical breast cancer sectionsSemantic proximity Read ↗

The impact of the 21-gene recurrence score assay on decision making about adjuvant chemotherapy in early-stage estrogen-receptor-positive breast cancer in an oncology practice with a unified treatment policy.Semantic proximity Read ↗

The Multi-Omic Transformation of Breast Cancer Diagnostics: A Comprehensive Review of the Transition from Immunohistochemistry to Liquid Biopsy and Next-Generation SequencingSemantic proximity Read ↗

Revolutionizing Detection of Minimal Residual Disease in Breast Cancer Using Patient-Derived Gene SignatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.