Article
Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.
Journal of the National Cancer Institute - 14 Dec 2020
Palmer Julie R, Polley Eric C, Hu Chunling, John Esther M, Haiman Christopher, Hart Steven N, Gaudet Mia, Pal Tuya, Anton-Culver Hoda, Trentham-Dietz Amy, Bernstein Leslie, Ambrosone Christine B, Bandera Elisa V, Bertrand Kimberly A, Bethea Traci N, Gao Chi, Gnanaolivu Rohan D, Huang Hongyan, Lee Kun Y, LeMarchand Loic, Na Jie, Sandler Dale P, Shah Payal D, Yadav Siddhartha, Yang William, Weitzel Jeffrey N, Domchek Susan M, Goldgar David E, Nathanson Katherine L, Kraft Peter, Yao Song, Couch Fergus J
Abstract excerpt
BACKGROUND: The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993...
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