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Article

Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases

30 Apr 2020

Abstract excerpt

Sirtuins are protein deacetylases that play a protective role in cardiovascular diseases as well as many other diseases. Absence of sirtuins can lead to hyper-acetylation of both nuclear and mitochondrial proteins leading to metabolic dysregulation. The protein posttranslational modifications (PTMs) are known to crosstalk among each other to bring about complex phenotypic outcomes. Various PTM types like...

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PMID: 32425973
DOI: 10.3389/fgene.2020.00356

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