Article
Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses.
Gut - 1 Feb 2021
Molina-Montes Esther, Coscia Claudia, Gómez-Rubio Paulina, Fernández Alba, Boenink Rianne, Rava Marta, Márquez Mirari, Molero Xavier, Löhr Matthias, Sharp Linda, Michalski Christoph W, Farré Antoni, Perea José, O'Rorke Michael, Greenhalf William, Iglesias Mar, Tardón Adonina, Gress Thomas M, Barberá Victor M, Crnogorac-Jurcevic Tatjana, Muñoz-Bellvís Luis, Dominguez-Muñoz J Enrique, Renz Harald, Balcells Joaquim, Costello Eithne, Ilzarbe Lucas, Kleeff Jörg, Kong Bo, Mora Josefina, O'Driscoll Damian, Poves Ignasi, Scarpa Aldo, Yu Jingru, Hidalgo Manuel, Lawlor Rita T, Ye Weimin, Carrato Alfredo, Real Francisco X, Malats Núria
Abstract excerpt
OBJECTIVES: To characterise the association between type 2 diabetes mellitus (T2DM) subtypes (new-onset T2DM (NODM) or long-standing T2DM (LSDM)) and pancreatic cancer (PC) risk, to explore the direction of causation through Mendelian randomisation (MR) analysis and to assess the mediation role of body mass index (BMI). DESIGN: Information about T2DM and related factors was collected from 2018 PC cases and 1540...
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