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Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy

1 May 2020

Abstract excerpt

ABSTRACT The sex-biased disease pulmonary arterial hypertension (PAH) is characterized by the proliferation and overgrowth of dysfunctional pulmonary artery endothelial cells (PAECs). During inflammation associated with PAH, granzyme B cleaves intersectin-1 to produce N-terminal (EHITSN) and C-terminal (SH3A–EITSN) protein fragments. In a murine model of PAH, EHITSN triggers plexiform arteriopathy via...

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PMID: 32409569
DOI: 10.1242/jcs.237776

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