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Article

Actin sequestering protein, profilin, regulates intracellular vesicle transport in Leishmania.

Molecular and biochemical parasitology - 1 Jul 2020

Ambaru Bindu, Gopalsamy Anupriya, Tammana T V Satish, Subramanya Hosahalli S, Gupta Chhitar M

Abstract excerpt

Profilins are the key regulators of actin dynamics in all eukaryotic cells. However, little information is available on their biochemical properties and functions in kinetoplastids, such as Trypanosoma and Leishmania. We show here that Leishmania parasites express only one homolog of profilin (LdPfn), which catalyzes nucleotide exchange on G-actin and promotes actin polymerization at its low concentrations....

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Identifiers

PMID: 32407750
DOI: 10.1016/j.molbiopara.2020.111280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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