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Article

Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum.

Structure (London, England : 1993) - 12 Nov 2008

Kursula Inari, Kursula Petri, Ganter Markus, Panjikar Santosh, Matuschewski Kai, Schüler Herwig

Abstract excerpt

Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microfilament system for motility and host cell invasion. Their genomes encode only a small number of divergent actin regulators. We present the first crystal structure of an apicomplexan profilin, that...

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Identifiers

PMID: 19000816
DOI: 10.1016/j.str.2008.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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