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Toxofilin, a Novel Actin-binding Protein fromToxoplasma gondii, Sequesters Actin Monomers and Caps Actin Filaments

1 Jan 2000

Abstract excerpt

Toxoplasma gondii relies on its actin cytoskeleton to glide and enter its host cell. However, T. gondii tachyzoites are known to display a strikingly low amount of actin filaments, which suggests that sequestration of actin monomers could play a key role in parasite actin dynamics. We isolated a 27-kDa tachyzoite protein on the basis of its ability to bind muscle G-actin and demonstrated that it interacts with...

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PMID: 10637313
DOI: 10.1091/mbc.11.1.355

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