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Article

Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17).

Cell proliferation - 1 Jun 2020

Bi Chun-Sheng, Li Xuan, Qu Hong-Lei, Sun Li-Juan, An Ying, Hong Yong-Long, Tian Bei-Min, Chen Fa-Ming

Abstract excerpt

OBJECTIVES: Previously, we found that by regulating T helper (Th) cell polarization, calcitriol intervention inhibited lipopolysaccharide (LPS)-induced alveolar bone loss in an animal periodontitis model, but the underlying cellular events remain unknown. MATERIALS AND METHODS: In this study, mouse Th cells were incubated in an inflammatory environment in the presence of dendritic cells (DCs) and LPS. Then, the...

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PMID: 32406154
DOI: 10.1111/cpr.12827
PMCID: PMC7309596

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