Article
Developing effective screening strategies in multiple endocrine neoplasia type 1 (MEN 1) on the basis of clinical and sequencing data of German patients with MEN 1.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Sept 2007
Schaaf L, Pickel J, Zinner K, Hering U, Höfler M, Goretzki P E, Spelsberg F, Raue F, von zur Mühlen A, Gerl H, Hensen J, Bartsch D K, Rothmund M, Schneyer U, Dralle H, Engelbach M, Karges W, Stalla G K, Höppner W
Abstract excerpt
BACKGROUND: Multiple-endocrine-neoplasia-type-1 (MEN1) is an autosomal-dominant inherited disorder characterized by the combined occurrence of primary hyperparathyroidism (pHPT), gastroenteropancreatic neuroendocrine tumors (GEP), adenomas of the pituitary gland (APA), adrenal cortical tumors (ADR) and other tumors. As the tumors appear in an unpredictable schedule, uncertainty about screening programs is...
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