Article
Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D-binding protein isoforms.
International journal of cancer - 15 Nov 2020
Gibbs David Corley, Bostick Roberd M, McCullough Marjorie L, Um Caroline Y, Flanders W Dana, Jenab Mazda, Weiderpass Elisabete, Gylling Björn, Gram Inger T, Heath Alicia K, Colorado-Yohar Sandra, Dahm Christina C, Bueno-de-Mesquita Bas, Perez-Cornago Aurora, Trichopoulou Antonia, Tumino Rosario, Kühn Tilman, Fedirko Veronika
Abstract excerpt
Lower prediagnostic circulating 25-hydroxyvitamin D (25[OH]D)-considered the best marker of total vitamin D exposure-is associated with higher mortality risk among colorectal cancer (CRC) patients. However, it is unknown whether this association differs by the vitamin D-binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify...
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