Article
The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2008
Abbas Sascha, Linseisen Jakob, Slanger Tracy, Kropp Silke, Mutschelknauss Elke Jonny, Flesch-Janys Dieter, Chang-Claude Jenny
Abstract excerpt
Vitamin D pathway gene polymorphisms may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D. The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-hydroxyvitamin D [25(OH)D], the biomarker for vitamin D status in humans, has not been examined thus far. We assessed...
Topics
- Aged
- Alleles
- Analysis of Variance
- Breast Neoplasms
- Case-Control Studies
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Logistic Models
- Middle Aged