Article
Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria.
Malaria journal - 8 May 2020
Dossou-Yovo Louis Regis, Ntoumi Francine, Koukouikila-Koussounda Felix, Vouvoungui Jeannhey Christevy, Adedoja Ayodele, Nderu David, Velavan Thirumalaisamy P, Lenga Arsène
Abstract excerpt
BACKGROUND: Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and eradication programmes. Plasmodium falciparum multiple drug resistance-1 gene (Pfmdr1) N86Y mutation is associated with reduced susceptibility to lumefantrine. This...
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