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Article

CRY1-CBS binding regulates circadian clock function and metabolism.

The FEBS journal - 1 Jan 2021

Cal-Kayitmazbatir Sibel, Kulkoyluoglu-Cotul Eylem, Growe Jacqueline, Selby Christopher P, Rhoades Seth D, Malik Dania, Oner Hasimcan, Asimgil Hande, Francey Lauren J, Sancar Aziz, Kruger Warren D, Hogenesch John B, Weljie Aalim, Anafi Ron C, Kavakli Ibrahim Halil

Abstract excerpt

Circadian disruption influences metabolic health. Metabolism modulates circadian function. However, the mechanisms coupling circadian rhythms and metabolism remain poorly understood. Here, we report that cystathionine β-synthase (CBS), a central enzyme in one-carbon metabolism, functionally interacts with the core circadian protein cryptochrome 1 (CRY1). In cells, CBS augments CRY1-mediated repression of the...

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Identifiers

PMID: 32383312
DOI: 10.1111/febs.15360
PMCID: PMC7648728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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