Article
LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma.
Cell death & disease - 7 May 2020
Chang Ting-Han, Shanti Rabie M, Liang Yanfang, Zeng Jincheng, Shi Shihong, Alawi Faizan, Carrasco Lee, Zhang Qunzhou, Le Anh D
Abstract excerpt
Ameloblastoma (AM) is a benign but locally aggressive tumor with high recurrences. Currently, underlying pathophysiology remains elusive, and radical surgery remains the most definitive treatment with severe morbidities. We have recently reported that AM harbors a subpopulation of tumor epithelial stem-like cells (AM-EpiSCs). Herein, we explored whether LGR5+ epithelial cells in AM possess stem-like cell...
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