Article
Omadacycline invitro activity against a molecularly characterized collection of clinical isolates with known acquired tetracycline resistance mechanisms.
Diagnostic microbiology and infectious disease - 1 Jul 2020
Mendes Rodrigo E, Huband Michael D, Streit Jennifer M, Castanheira Mariana, Flamm Robert K
Abstract excerpt
Omadacycline and tigecycline MIC90 values were 2 μg/mL and 0.25 μg/mL, respectively, against Staphylococcus aureus carrying tet(M), whereas the minocycline, tetracycline, and doxycycline values were > 8 μg/mL. Similarly, omadacycline and tigecycline remained active against Enterococcus faecalis and Streptococcus pneumoniae harboring tet(L)and/or tet(M)(MIC90, 0.06-0.25 μg/mL), whereas other tetracyclines were...
Topics
- Anti-Bacterial Agents
- Bacteria
- Bacterial Proteins
- Genotype
- Humans
- Microbial Sensitivity Tests
- Tetracycline Resistance
- Tetracyclines
- Tigecycline