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Article

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine.

Cell reports - 5 May 2020

Dijkstra Krijn K, Monkhorst Kim, Schipper Luuk J, Hartemink Koen J, Smit Egbert F, Kaing Sovann, de Groot Rosa, Wolkers Monika C, Clevers Hans, Cuppen Edwin, Voest Emile E

Abstract excerpt

Clinical implementation of tumor organoids for personalized medicine requires that pure tumor organoids can be reliably established. Here, we present our experience with organoid cultures from >70 non-small cell lung cancer (NSCLC) samples. We systematically evaluate several methods to identify tumor purity of organoids established from intrapulmonary tumors. Eighty percent of organoids from intrapulmonary...

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PMID: 32375033
DOI: 10.1016/j.celrep.2020.107588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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