Article
Functional polymorphisms in UDP-glucuronosyl transferases and recurrence in tamoxifen-treated breast cancer survivors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2011
Ahern Thomas P, Christensen Mariann, Cronin-Fenton Deirdre P, Lunetta Kathryn L, Søiland Håvard, Gjerde Jennifer, Garne Jens Peter, Rosenberg Carol L, Silliman Rebecca A, Sørensen Henrik Toft, Lash Timothy L, Hamilton-Dutoit Stephen
Abstract excerpt
BACKGROUND: Tamoxifen is oxidized by cytochrome-P450 enzymes (e.g., CYP2D6) to two active metabolites, which are eliminated via glucuronidation by UDP-glucuronosyl transferases (UGT). We measured the association between functional polymorphisms in key UGTs (UGT2B15*2, UGT2B7*2, and UGT1A8*3) and the recurrence rate among breast cancer survivors. METHODS: We used the Danish Breast Cancer Cooperative Group registry...
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