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Article

Enrichment of kinase fusions in ESR1 wild-type, metastatic breast cancer revealed by a systematic analysis of 4854 patients.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Aug 2020

Ross D S, Liu B, Schram A M, Razavi P, Lagana S M, Zhang Y, Scaltriti M, Bromberg J F, Ladanyi M, Hyman D M, Drilon A, Zehir A, Benayed R, Chandarlapaty S, Hechtman J F

Abstract excerpt

BACKGROUND: Kinase fusions are rare and poorly characterized in breast cancer (BC). We aimed to characterize kinase fusions within a large cohort of advanced BC. PATIENTS AND METHODS: A total of 4854 patients with BC were analyzed by Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) targeted DNAseq and MSK-Fusion targeted RNAseq during the study time period. RESULTS:...

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PMID: 32348852
DOI: 10.1016/j.annonc.2020.04.008
PMCID: PMC7396305

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