Article
A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria.
Cell host & microbe - 10 Jun 2020
Bisanz Jordan E, Soto-Perez Paola, Noecker Cecilia, Aksenov Alexander A, Lam Kathy N, Kenney Grace E, Bess Elizabeth N, Haiser Henry J, Kyaw Than S, Yu Feiqiao B, Rekdal Vayu M, Ha Connie W Y, Devkota Suzanne, Balskus Emily P, Dorrestein Pieter C, Allen-Vercoe Emma, Turnbaugh Peter J
Abstract excerpt
Despite the remarkable microbial diversity found within humans, our ability to link genes to phenotypes is based upon a handful of model microorganisms. We report a comparative genomics platform for Eggerthella lenta and other Coriobacteriia, a neglected taxon broadly relevant to human health and disease. We uncover extensive genetic and metabolic diversity and validate a tool for mapping phenotypes to genes and...
Topics
- Actinobacteria
- Animals
- Anti-Bacterial Agents
- Bacteria
- Dissection
- Gastrointestinal Microbiome
- Gastrointestinal Tract
- Genes, Bacterial
- Genomics
- Germ-Free Life