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Article

Novel variant in CHRNA4 with benign childhood epilepsy with centrotemporal spikes and contribution to precise medicine.

Molecular genetics & genomic medicine - 1 Jul 2020

Neng Xiao, Xiao Mao, Yuanlu Chen, Qinyan Li, Li Shu, Zhanyi Song

Abstract excerpt

BACKGROUND: Benign childhood epilepsy with centrotemporal spikes (BECTS) or benign rolandic epilepsy is the most common epileptic syndrome in school-age children. Genetics is an important factor in BECTS pathogenesis, and <10 genes were associated with BECTS. This study aimed to identify novel genetic causes of BECTS. METHODS: We conducted whole-exome sequencing on a patient with BECTS and validated the findings...

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Identifiers

PMID: 32342646
DOI: 10.1002/mgg3.1264
PMCID: PMC7336761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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