Article
Emergence of Mycobacterium leprae Rifampin Resistance Evaluated by Whole-Genome Sequencing after 48 Years of Irregular Treatment.
Antimicrobial agents and chemotherapy - 23 Jun 2020
Avanzi Charlotte, Maia Raquel Cristina, Benjak Andrej, Nery José Augusto, Sales Anna Maria, Miranda Alice, Duppre Nadia Cristina, Nogueira Brum Fontes Amanda, Pereira da Silva Tatiana, Olmo Pinheiro Roberta, Neves-Manta Fernanda, Moreira Suelen Justo Maria, Busso Philippe, Sarno Euzenir Nunes, Suffys Phillip Noel, Cole Stewart Thomas, Moraes Milton Ozório
Abstract excerpt
A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also detected. Clinical improvement was achieved using an alternative therapy.
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