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Article

Possible Role of Amyloidogenic Evolvability in Dementia with Lewy Bodies: Insights from Transgenic Mice Expressing P123H β-Synuclein.

International journal of molecular sciences - 19 Apr 2020

Fujita Masayo, Ho Gilbert, Takamatsu Yoshiki, Wada Ryoko, Ikeda Kazutaka, Hashimoto Makoto

Abstract excerpt

Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia after Alzheimer's disease, and is pathologically characterized by formation of intracellular inclusions called Lewy bodies, the major constituent of which is aggregated α-synuclein (αS). Currently, neither a mechanistic etiology nor an effective disease-modifying therapy for DLB has been established. Although two missense...

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PMID: 32325870
DOI: 10.3390/ijms21082849
PMCID: PMC7215759

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