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Article

A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.

Biochemistry - 25 Nov 2008

Yukl Erik T, Ioanoviciu Alexandra, Nakano Michiko M, de Montellano Paul R Ortiz, Moënne-Loccoz Pierre

Abstract excerpt

DevS is a heme-based sensor kinase required for sensing environmental conditions leading to nonreplicating persistence in Mycobacterium tuberculosis. Kinase activity is observed when the heme is a ferrous five-coordinate high-spin or six-coordinate low-spin CO or NO complex but is strongly inhibited in the oxy complex. Discrimination between these exogenous ligands has been proposed to depend on a specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18975917
DOI: 10.1021/bi801234w
PMCID: PMC2666047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A distal tyrosine residue is required for ligand discrimination in DevS from Mycobacterium tuberculosis.PMID 18975917Read ↗

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Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes.Semantic proximity Read ↗

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