Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT2 is involved in the modulation of depressive behaviors.

Scientific reports - 12 Feb 2015

Liu Rui, Dang Wei, Du Ying, Zhou Qiong, Jiao Kai, Liu Zhaohui

Abstract excerpt

Exposure to chronic stress produces negative effects on mood and hippocampus-dependent memory formation. SIRT2 alteration has been reported in mood disorders; however, the role of SIRT2 in depression remains unclear. Therefore, we aimed to determine whether SIRT2 can restore stress-induced suppression of neurogenesis in a rat chronic unpredictable stress (CUS) model of depression. Sucrose preference test,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anilides
Share to Behavior, Animal
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hippocampus

Share to Neurogenesis

Share to Sirtuin 2

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 25672834
DOI: 10.1038/srep08415
PMCID: PMC4325337

Genes

SIRT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT2 is involved in the modulation of depressive behaviors.PMID 25672834Read ↗

Hippocampal Sirtuin 1 Signaling Mediates Depression-like BehaviorSemantic proximity Read ↗

miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in HippocampusSemantic proximity Read ↗

Role of the Sirt6/Hmgb1 pathway in neuroinflammation of Sleep deprivation-induced depressed miceSemantic proximity Read ↗

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic MechanismsSemantic proximity Read ↗

Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice.Semantic proximity Read ↗

Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders.Semantic proximity Read ↗

Stress modulates Ahi1-dependent nuclear localization of ten-eleven translocation protein 2.Semantic proximity Read ↗

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of DepressionSemantic proximity Read ↗

Therapeutic role of long non-coding RNA TCONS_00019174 in depressive disorders is dependent on Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

Enriched environment mitigates depressive behavior by changing the inflammatory activation phenotype of microglia in the hippocampus of depression model rats.Semantic proximity Read ↗

MiR-155 is involved in major depression disorder and antidepressant treatment via targeting SIRT1Semantic proximity Read ↗

RNA-Seq analysis of Dendrobium nobile Lindl. alkaloids (DNLA) protection against CUMS-induced anxiety and depression in Fawn-Hooded (FH/Wjd) ratsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.