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Article

Elucidating the regulation of glucose tolerance in a β-glucosidase from Halothermothrix orenii by active site pocket engineering and computational analysis.

International journal of biological macromolecules - 1 Aug 2020

Sinha Sushant K, Das Shibashis, Konar Sukanya, Ghorai Pradip Kr, Das Rahul, Datta Supratim

Abstract excerpt

β-Glucosidase catalyzes the hydrolysis of β-1,4 linkage between two glucose molecules in cello-oligosaccharides and is prone to inhibition by the reaction product glucose. Relieving the glucose inhibition of β-glucosidase is a significant challenge. Towards the goal of understanding how glucose interacts with β-glucosidase, we expressed in Escherichia coli, the Hore_15280 gene encoding a β-glucosidase in...

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PMID: 32304787
DOI: 10.1016/j.ijbiomac.2020.04.036

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