Article
High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma.
World journal of urology - 1 Feb 2021
Eichenauer Till, Simmendinger Luca, Fraune Christoph, Mandelkow Tim, Blessin Niclas C, Kluth Martina, Hube-Magg Claudia, Möller Katharina, Clauditz Till, Weidemann Sören, Dahlem Roland, Fisch Margit, Riechardt Silke, Simon Ronald, Sauter Guido, Büscheck Franziska, Rink Michael
Abstract excerpt
PURPOSE: Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity. METHODS: To investigate whether the prognostic role of EZH2 might be driven by a modified immune environment, more than 1800 RCCs were analyzed in a tissue...
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