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Article

Neutrophils expressing lysyl oxidase-like 4 protein are present in colorectal cancer liver metastases resistant to anti-angiogenic therapy.

The Journal of pathology - 1 Jun 2020

Palmieri Vincent, Lazaris Anthoula, Mayer Thomas Z, Petrillo Stephanie K, Alamri Hussam, Rada Miran, Jarrouj George, Park Woong-Yang, Gao Zu-Hua, McDonald Patrick P, Metrakos Peter

Abstract excerpt

Colorectal cancer liver metastases (CRCLM) that present with a replacement histopathological growth pattern (HGP) are resistant to neoadjuvant anti-angiogenic therapy. Surrogate biomarkers are not available to preoperatively identify patients with these tumors. Here we identify differentially expressed genes between CRCLM with a replacement HGP and those with a desmoplastic HGP using RNA sequencing. We...

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Identifiers

PMID: 32297656
DOI: 10.1002/path.5449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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