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Article

Broken beyond repair: TA system ParE toxins mediate effective gyrase inhibition without driving resistance.

Journal of bacteriology - 20 Mar 2025

Tu Chih-Han, Ruan Shengfeng, Holt Michelle, Bourne Christina R

Abstract excerpt

DNA gyrase is an essential bacterial-specific type IIA topoisomerase that corrects DNA overwinding during transcription and replication. Compounds capable of stabilizing gyrase-mediated double-strand DNA breaks are valuable antibacterials; however, these can trigger error-prone repair, potentially inducing DNA mutations leading to antimicrobial resistance. ParE toxin proteins, which belong to a family of type II...

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Topics

DNA Gyrase
Anti-Bacterial Agents
Bacterial Toxins
Drug Resistance, Bacterial
Toxin-Antitoxin Systems
DNA Topoisomerase IV

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Topoisomerase II Inhibitors

Microbial Sensitivity Tests

Bacterial Proteins

Mutation

Source

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Identifiers

PMID: 40029095
DOI: 10.1128/jb.00416-24
PMCID: PMC11925232

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