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Article

Characterization of human-induced pluripotent stem cells carrying homozygous RB1 gene deletion.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2020

Deng Xiaoyue, Iwagawa Toshiro, Fukushima Masaya, Watanabe Sumiko

Abstract excerpt

Retinoblastoma is an infant cancer that results from loss of RB1 expression in both alleles. The RB1 gene was the first reported cancer suppressor gene; however, the mechanism by which RB1 loss causes cancer in the retina has not yet been clarified. Human-induced pluripotent stem cells (iPSCs) provide an ideal tool for mechanistic research regarding retinoblastoma. However, because RB1 is a tumor suppressor, loss...

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Identifiers

PMID: 32277725
DOI: 10.1111/gtc.12771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of human-induced pluripotent stem cells carrying homozygous RB1 gene deletion.PMID 32277725Read ↗

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