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Article

Generation of two H1 hESC sublines carrying a heterozygous and homozygous knock-out of RB1.

Stem cell research - 1 Dec 2017

Steenpass Laura

Abstract excerpt

Retinoblastoma is a childhood cancer of the retina caused by biallelic inactivation of the tumor suppressor gene RB1. In heritable retinoblastoma, one allele is inherited in mutant form via one of the parental germ cells. To study molecular mechanisms in retinoblastoma, two sublines of H1 hESCs were generated, carrying a knock-out allele of RB1 in the heterozygous or homozygous state. Exon 3 of RB1 was targeted...

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Source

Identifiers

PMID: 29246572
DOI: 10.1016/j.scr.2017.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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