Article
The impact of ABCB1 gene polymorphism and its expression on non-small-cell lung cancer development, progression and therapy - preliminary report.
Scientific reports - 10 Apr 2020
Zawadzka Izabela, Jeleń Agnieszka, Pietrzak Jacek, Żebrowska-Nawrocka Marta, Michalska Katarzyna, Szmajda-Krygier Dagmara, Mirowski Marek, Łochowski Mariusz, Kozak Józef, Balcerczak Ewa
Abstract excerpt
The ABCB1 gene belongs to ATP binding cassette (ABC) transporter genes that has been previously implicated in cancer progression and drug response. This study aimed to evaluate the association between the SNP 3435 and the expression of the ABCB1 gene in lung cancer patients in the Polish population in comparison to clinicopathological parameters and treatment. 150 RNA and 47 DNA samples were isolated from 49 lung...
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