Article
High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes for Hereditary Melanoma.
Genes - 8 Apr 2020
Campos Catarina, Fragoso Sofia, Luís Rafael, Pinto Filipe, Brito Cheila, Esteves Susana, Pataco Margarida, Santos Sidónia, Machado Patrícia, Vicente João B, Rosa Joaninha Costa, Cavaco Branca M, Moura Cecília, Pojo Marta
Abstract excerpt
Cutaneous melanoma is one of the most aggressive human cancers due to its high invasiveness. Germline mutations in high-risk melanoma susceptibility genes have been associated with development hereditary melanoma; however, most genetic culprits remain elusive. To unravel novel susceptibility genes for hereditary melanoma, we performed whole exome sequencing (WES) on eight patients with multiple primary melanomas,...
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