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Article

Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma.

Scientific reports - 9 Apr 2020

Cao Hongnan, Jin Miao, Gao Mu, Zhou Hongyi, Tao Yizhi Jane, Skolnick Jeffrey

Abstract excerpt

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer whose median survival time is under one year. The possible roles of the two most common DIPG associated cytoplasmic ACVR1 receptor kinase domain mutants, G328V and R206H, are reexamined in the context of new biochemical results regarding their intrinsic relative ATPase activities. At 37 °C, the G328V mutant displays a 1.8-fold increase in...

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Identifiers

PMID: 32273545
DOI: 10.1038/s41598-020-63061-0
PMCID: PMC7145857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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