Article
Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression.
eLife - 9 Apr 2020
Tsang Yiu Huen, Wang Yumeng, Kong Kathleen, Grzeskowiak Caitlin, Zagorodna Oksana, Dogruluk Turgut, Lu Hengyu, Villafane Nicole, Bhavana Venkata Hemanjani, Moreno Daniela, Elsea Sarah H, Liang Han, Mills Gordon B, Scott Kenneth L
Abstract excerpt
The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Here we show that a number of cancer-associated MAGEA mutants that undergo proteasome-dependent degradation in vitro could negatively impact their utility as immunotherapeutic targets. Importantly, in pancreatic...
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