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Article

CDH1 Mutation Distribution and Type Suggests Genetic Differences between the Etiology of Orofacial Clefting and Gastric Cancer.

Genes - 3 Apr 2020

Selvanathan Arthavan, Nixon Cheng Yee, Zhu Ying, Scietti Luigi, Forneris Federico, Uribe Lina M Moreno, Lidral Andrew C, Jezewski Peter A, Mulliken John B, Murray Jeffrey C, Buckley Michael F, Cox Timothy C, Roscioli Tony

Abstract excerpt

Pathogenic variants in CDH1, encoding epithelial cadherin (E-cadherin), have been implicated in hereditary diffuse gastric cancer (HDGC), lobular breast cancer, and both syndromic and non-syndromic cleft lip/palate (CL/P). Despite the large number of CDH1 mutations described, the nature of the phenotypic consequence of such mutations is currently not able to be predicted, creating significant challenges for...

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Identifiers

PMID: 32260281
DOI: 10.3390/genes11040391
PMCID: PMC7231129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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