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Article

Tumor Mutation Burden and Depression in Lung Cancer: Association With Inflammation.

Journal of the National Comprehensive Cancer Network : JNCCN - 1 Apr 2020

McFarland Daniel C, Jutagir Devika R, Miller Andrew H, Breitbart William, Nelson Christian, Rosenfeld Barry

Abstract excerpt

BACKGROUND: Patients with lung cancer with greater systemic inflammation have higher rates of depression. Tumor mutation burden (TMB) predicts immunotherapy response in patients with lung cancer and is associated with intratumoral inflammation, which may contribute to systemic inflammation and depression. This study evaluated whether higher TMB was associated with increased depression and systemic inflammation in...

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Identifiers

PMID: 32259781
DOI: 10.6004/jnccn.2019.7374
PMCID: PMC7327956

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