A Latent profile and network intervention analysis of psychosomatic symptoms in lung cancer immunotherapy patients.

doi:10.1371/journal.pone.0357460

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Article

A Latent profile and network intervention analysis of psychosomatic symptoms in lung cancer immunotherapy patients.

PloS one - 1 Jan 2026

Zheng Danwen, Gao Hang, Zou Yanfei, Shao Qiuyue, Yu Xinyan, Qiu Lanying, Sun Xiaoli

Abstract excerpt

BACKGROUND: Immune checkpoint inhibitors improve non-small cell lung cancer prognosis but induce complex, heterogeneous psychosomatic symptoms. Traditional symptom-focused approaches fail to capture underlying patient heterogeneity and interaction mechanisms. METHODS: In this cross-sectional study of 971 lung cancer patients undergoing immunotherapy, symptom phenotypes were identified using Latent Profile...

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Topics

Humans
Female
Lung Neoplasms
Male
Middle Aged
Immunotherapy
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Symptom Burden

Psychophysiologic Disorders

Carcinoma, Non-Small-Cell Lung

Risk Factors

Phenotype

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 42715182
DOI: 10.1371/journal.pone.0357460
PMCID: PMC13557409

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