Article
Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study.
Journal of affective disorders - 15 Jun 2023
Henry Melissa, Harvey Raphaële, Chen Lawrence M, Meaney Michael, Nguyen Thi Thu Thao, Kao Han-Tin, Rosberger Zeev, Frenkiel Saul, Hier Michael, Zeitouni Anthony, Kost Karen, Mlynarek Alex, Richardson Keith, Greenwood Celia M T, Melnychuk David, Gold Phil, Chartier Gabrielle, Black Martin, Mascarella Marco, MacDonald Christina, Sadeghi Nader, Sultanem Khalil, Shenouda Georges, Cury Fabio, O'Donnell Kieran John
Abstract excerpt
OBJECTIVE: The primary purpose of this study was to investigate the contribution of genetic predispositions to depression and inflammation, as measured through polygenic risk scores, on symptom burden (physical and psychological) in patients with head and neck cancer in the immediate post-treatment period (i.e., at three months post-diagnosis), as well as on 3-, 6-, 12-, 24- and 36-month survival. METHODS:...
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