Article
Association of ABO blood group and antituberculosis drug-induced liver injury: A case-control study from a Chinese Han population.
Journal of clinical pharmacy and therapeutics - 1 Aug 2020
Tao Bilin, Yang Miaomiao, Chen Hongbo, Pan Hongqiu, Liu Wenpei, Yi Honggang, Tang Shaowen
Abstract excerpt
WHAT IS KNOWN AND OBJECTIVE: Antituberculosis drug-induced liver injury (ATLI) is a serious adverse drug reaction, and its pathogenic mechanism is still largely unknown. Rifampin (RIF) has been reported to cause haemolysis due to the production of drug-dependent antibodies, and haemolysis results in an increased level of free haem, which affects the function of hepatocytes. Blood group determinants can act as...
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