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Article

Potential Pathogenic Genes Prioritization Based on Protein Domain Interaction Network Analysis.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Wang Wenyan, Zhou Yuming, Cheng Mu-Tian, Wang Yan, Zheng Chun-Hou, Xiong Yan, Chen Peng, Ji Zhiwei, Wang Bing

Abstract excerpt

Pathogenicity-related studies are of great importance in understanding the pathogenesis of complex diseases and improving the level of clinical medicine. This work proposed a bioinformatics scheme to analyze cancer-related gene mutations, and try to figure out potential genes associated with diseases from the protein domain-domain interaction network. Herein, five measures of the principle of centrality lethality...

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PMID: 32248121
DOI: 10.1109/TCBB.2020.2983894

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