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Article

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

3 Apr 2020

Abstract excerpt

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor binding domain...

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Identifiers

PMID: 32245784
DOI: 10.1126/science.abb7269

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