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Article

Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody

21 Oct 2021

Abstract excerpt

Abstract An essential step for SARS‐CoV‐2 infection is the attachment to the host cell receptor by its Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing antibodies block the receptor‐binding motif (RBM), a mutable region with the potential to generate neutralization escape mutants. Here, we isolated and structurally characterized a non‐RBM‐targeting monoclonal antibody (FD20)...

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Identifiers

PMID: 34672091
DOI: 10.15252/emmm.202114544

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