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Article

Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.

Stem cell reports - 14 Apr 2020

Boles Nathan C, Fernandes Marie, Swigut Tomasz, Srinivasan Rajini, Schiff Lauren, Rada-Iglesias Alvaro, Wang Qingjie, Saini Janmeet S, Kiehl Thomas, Stern Jeffrey H, Wysocka Joanna, Blenkinsop Timothy A, Temple Sally

Abstract excerpt

Epithelial to mesenchymal transition (EMT) is a biological process involved in tissue morphogenesis and disease that causes dramatic changes in cell morphology, migration, proliferation, and gene expression. The retinal pigment epithelium (RPE), which supports the neural retina, can undergo EMT, producing fibrous epiretinal membranes (ERMs) associated with vision-impairing clinical conditions, such as macular...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32243845
DOI: 10.1016/j.stemcr.2020.03.009
PMCID: PMC7160390

Genes

RPE
PVR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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